- This Program Announcement will provide resources to validate candidate biomarkers for well-defined human diseases of liver, kidney, urological tract, digestive and hematologic systems, and endocrine and metabolic disorders, diabetes and its complications, and obesity, for which there are no or very few biomarkers, or for which standard biomarkers are currently prohibitively invasive or expensive. A biomarker is an indicator of a disease process, and could replace hard clinical end points as a measure of the effect of new therapies. Responsive studies will validate candidate biomarkers in well-defined patient populations, provide new technologies to monitor biomarkers or establish reliable assays for validated markers.
- Allowable mechanisms include the investigator-initiated regular research project grant (R01) and the Exploratory/Development Research grant (R21).
- Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.
- For-profit and non-profit organizations are eligible, including public or private institutions, units of state and local governments, eligible agencies of the federal government, domestic or foreign institutions/organizations, and faith-based or community-based organizations.
- Any individual with the requisite skills and experience to direct the type of research described in this RFA is eligible to apply as a principal investigator. Women and members of underrepresented groups are especially encouraged to apply.
- Applicants may submit more than one application, provided they are scientifically distinct.
- Applications must be prepared using the PHS 398 research grant application instructions and forms (http://grants.nih.gov/grants/funding/phs398/phs398.html).
- Telecommunications for the hearing impaired is available at: TTY 301-451-0088
Who can apply:
City Or Township Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)
Eligible functional categories:
Alcohol Research Programs
Diabetes, Endocrinology and Metabolism Research
Digestive Diseases and Nutrition Research
Discovery and Applied Research
Kidney Diseases, Urology and Hematology Research
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